Core Outcome Measures in Effectiveness Trials

COMET Initiative

The COMET (Core Outcome Measures in Effectiveness Trials) Initiative brings together people interested in the development and application of agreed standardised sets of outcomes, known as ‘core outcome sets’ (COS). These sets represent the minimum that should be measured and reported in all clinical trials of a specific condition, and are also suitable for use in clinical audit or research other than randomised trials. The existence or use of a core outcome set does not imply that outcomes in a particular trial should be restricted to those in the relevant core outcome set. Rather, there is an expectation that the core outcomes will be collected and reported, making it easier for the results of trials to be compared, contrasted and combined as appropriate; while researchers continue to explore other outcomes as well. COMET aims to collate and stimulate relevant resources, both applied and methodological, to facilitate exchange of ideas and information, and to foster methodological research in this area.

When searching the COMET database, please note that a systematic review is currently underway to identify eligible material, and we are continually updating the database as we identify eligible studies. Therefore, the records retrieved by any search might increase on a daily basis.

The COMET database currently contains 857 references of planned, ongoing and completed work.

The keyword used for the search will be compared with study title, abstract and author's surname.

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To view a demonstration of how to search the COMET database click here

Core resource pack

Useful references for core outcome set developers.

This includes an overview of the problems with outcomes in trials, key issues to consider in the development of a core outcome set, examples of core outcome set development, and things to think about once a COS is agreed. To read more, click here.

Latest News

  • Wednesday 21 September, 2016 - How to select outcome measurement instruments for outcomes included in a "Core Outcome Set" - a practical guideline.

    A new consensus based guideline for selecting outcome measurement instruments has recently been published in Trials.

    In collaboration with the COMET Initiative, the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) initiative have developed a guideline on how to select outcome measurement instruments for outcomes (i.e., constructs or domains) included in a "Core Outcome Set" (COS). This guideline can be used by COS developers in defining how to measure core outcomes.

    Read the full paper here.

  • Monday 11 July, 2016 - Including patients in core outcome set development: issues to consider

    The authors report on three interactive workshops that explored how patients and the public can contribute to decision making about what outcomes should be included in a COS. About 100 international delegates, including researchers, clinicians and patients, attended the workshops. The workshops were held in the United Kingdom, Italy and Canada as part of the COMET (Core Outcome Measures in Effectiveness Trials) Initiative annual meetings. Read the full paper here.

  • Thursday 30 June, 2016 - COMET VI registration now open

    We are pleased to announce that registration for COMET VI is now open. You can register here.

    You can also submit an abstract for presentation at COMET VI.

    We look forward to seeing you in Amsterdam.

Recently Added Studies

  • Development of a core outcome set based on Case Report Form (CRF) to assess laboratory biomarkers and clinical parameters in Onco-Hematology area

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  • Development of a core outcome data set based on consensus standardized (COD Dementia) to assess mild to moderate dementia with MOCA and laboratory biomarkers in Nursing Home

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  • Identification of outcome domains measured in the management of paediatric lateral humeral condyle fractures. A Systematic review.

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  • The CO-OPT Study: Core Outcomes in Obstetric Anal Sphincter Injury Prevention and Treatment

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  • Development of a core outcome set for Pelvic Girdle Pain; A systematic review, qualitative interviews and Delphi consensus study

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