COVID-19 Core outcomes set: COVID-19-COS

COVID-19-COS is conducted as part of the National COVID-19 Clinical Evidence Taskforce by the Australian Living Evidence Consortium to ensure that consensus-based high priority outcomes are consistently included in guidelines for the clinical management of patients with suspected or proven COVID-19 infection across primary, acute and critical care settings. The COS is also intended to be implemented in trials in people with suspected or confirmed COVID-19.

PHASE 1 | Systematic review of outcomes in registered and published trials in patients with confirmed or suspected 2019-nCoV

We will conduct a systematic review to identify and assess the scope and consistency of outcomes reported in randomised controlled trials (RCTs) of interventions in patients with confirmed or suspected COVID-19.

PHASE 2 | Delphi survey
We will conduct an international online two-round Delphi survey with patients, caregivers, community members and health professionals to gain consensus on the outcome domains that are critically important to all stakeholder groups for trials in COVID-19.

PHASE 3 | Consensus workshops
We will conduct a series of three web-based consensus workshops on zoom over three consecutive days (each workshop will be 2 hours in duration with approximately 60 patients, caregivers, community members and health professionals; total 180) to obtain feedback and discuss the proposed core outcomes for COVID-19. The online consensus workshops will be conducted in English chaired by a member of investigator team.

Aim

To establish a core outcome set for research in patients with confirmed or suspected 2019-nCoV.

Contributors

Julian Elliot, Monash University and Cochrane Australia
Jonathan Craig, Flinders University
Armando Teixeira-Pinto, The University of Sydney
Martin Howell, The University of Sydney
Allison Tong, The University of Sydney

Further Study Information

Current Stage: Ongoing
Date: March 2020 - August 2020
Funding source(s): To be confirmed


Health Area

Disease Category: Infectious disease

Disease Name: Coronavirus

Target Population

Age Range: 18 - 100

Sex: Either

Nature of Intervention: Any

Stakeholders Involved

- Clinical experts
- Consumers (caregivers)
- Consumers (patients)
- Ethicists
- Families
- Pharmaceutical industry representatives
- Researchers

Study Type

- COS for clinical trials or clinical research

Method(s)

- Consensus conference
- Delphi process
- Literature review

Systematic review of outcomes reported in registered and published trials
International two-round Delphi survey
Three consecutive online consensus workshops

Stakeholder groups - ALL – its open to all given the nature of the condition