Core Outcome Measures in Effectiveness Trials

FP7 work package descriptions

Executive Group

Professor Paula Williamson, University of Liverpool, UK (Chair)
Professor Mike Clarke, Queens University Belfast, Ireland
Professor Maarten Boers, VU University, Netherlands
Dr Caroline Terwee, VU University, Netherlands

Work Package 1

The objectives of this work package are:

  1. To collate and increase evidence relevant to core outcome set (COS) development.
  2. To establish standards for methods of COS development.
  3. To increase the number of COS developed using evidence-based methods.
  4. To increase the impact of COS by raising awareness and increasing implementation.

Read progress report (Last updated: December 2012)

Choosing Important Health Outcomes for Comparative Effectiveness Research: A Systematic Review

Work Package 2

The two objectives of this Work Package are:

  1. To support engagement between the COMET Initiative, The Cochrane Collaboration and the GRADE Working Group.
  2. To develop a strategy to link the development of COS for trials with the specification of outcomes for Cochrane Reviews, including those to include in their Summary of Findings tables.

Read progress report (Last updated: December 2012)

Survey of new 2007 and 2011 Cochrane reviews found 37% of prespecified outcomes not reported

Work Package 3

This WP will provide methodological advice to groups developing core outcome sets, and raise awareness among clinical trialists. The specific objectives are:

  1. Provide advice to specific groups developing core outcome sets
  2. Provide advice to specific groups about planning the evaluation of the uptake of core outcome sets
  3. Develop best practices and increase human resource through a series of “network and best practice conferences”
  4. Evaluate the resources needed to roll this function out as the number of core outcome set projects increases.

Read progress report (Last updated: November 2012)

1st COMET Network meeting – 20th June 2013
2nd COMET Network meeting – 28th April 2014
3rd COMET Network meeting – 17th June 2014
4th COMET Network meeting – 16th September 2014

Work Package 4

This WP will provide support to COS developers on how the included outcomes in COS should be defined and measured. The specific objectives are:

  1. To identify ongoing research and relevant partners in the field of instrument selection
  2. To provide guidance and support to COS developers on how to find all measurement instruments that measure a specific core outcome
  3. To identify the essential information that should be gathered for each measurement instrument identified, including characteristics of the instrument and information on validity and reliability
  4. To collect available systematic reviews of measurement instruments
  5. To provide guidance and support to COS developers on how to perform systematic reviews of measurement instruments
  6. To provide guidance and support to COS developers on selecting instruments for COS
  7. To disseminate findings on measurement instruments among COS developers
  8. To develop a workshop on evidence-based instrument selection for COS developers

Read progress report (Last updated: December 2012)

Work Package 5

The overall aim of WP5 is to ensure the COMET programme achieves its aims. The objectives of this work package are:

  1. To ensure that the project is planned and managed professionally, so that it achieves its objectives, milestones and key deliverables on time, to a high standard and within budget, in accordance with the EC Grant Agreement.
  2. To ensure effective communication within and between WP teams.
  3. To arrange and manage Executive Group and International Advisory Group meetings.
  4. To monitor the progress of the project in accordance with the project schedule and deliverables, to identify and deal with risks, and to ensure that the project delivers the expected impacts.
  5. To ensure that financial reports and progress reports are submitted by partners in accordance with schedules.
  6. To submit annual financial, interim and periodic reports to the EC, in compliance with the reporting requirements of the EC Grant Agreement.
  7. To ensure that intellectual property rights are managed in accordance with the Consortium Agreement and to identify new opportunities for implementation and exploitation of project results.

Read progress report (Last updated: December 2012)

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