Core Outcome Measures in Effectiveness Trials

Systematic reviews of therapeutic interventions frequently consider patient-important outcomes

General Information

Abstract:
Objectives

To determine whether recently published and ongoing systematic reviews of therapeutic interventions assess patient-important outcomes.

Study Design and Setting

For this methodological review, we searched MEDLINE via PubMed for recently published systematic reviews and online registry of systematic reviews (PROSPERO) for ongoing systematic reviews. We selected systematic reviews with meta-analyses of randomized controlled trials. We extracted all outcomes defined in the methods section and categorized them. Mortality, other clinical events, pain, quality of life, function, and therapeutic decisions were considered patient-important outcomes.

Results

We included 420 systematic reviews: 90 Cochrane reviews, 200 other published reviews, and 130 registered ongoing reviews. Primary outcomes were defined in 85 Cochrane reviews (95%), 98 (49%) other published reviews and all ongoing reviews. At least one patient-important outcome was defined as a primary outcome in 81/85 Cochrane reviews (95%), 78/98 other published reviews (80%), and 117/130 ongoing reviews (90%). Considering all outcomes assessed, at least one patient-important outcome was evaluated in 90/90 Cochrane reviews (100%), 189/200 other published reviews (95%), and 121/130 ongoing reviews (93%).

Conclusion

Most recent systematic reviews aim to assess patient-important outcomes, which contrasts with RCTs. These results suggest some important gaps between primary and secondary research.

Keywords

Systematic reviews
Meta-analyses
Outcomes
Patient-important outcomes
Patient-reported outcomes
Patient-centered research
Comparative effectiveness research

Aim:
To determine whether recently published and ongoing systematic reviews of therapeutic interventions assess patient-important outcomes.

Authors:
Hayet Ameur
Philippe Ravaud
Florence Fayard
Carolina Riveros
Agnes Dechartres

Publication

Journal:
Journal of Clinical Epidemiology
Volume:
84
Issue:
Pages:
70 - 77
Year:
2017
DOI:
Further Study Information

Date:
Funding source(s):
The researchers did not receive external sources of funding.

Health Area

Disease Category
Other

Disease Name
N/A

Target Population

Age Range
0 - 110

Sex
Either


Nature / type of Intervention
N/A

Method(s)

Systematic review

Stakeholders Involved

Researchers

Study Type

Systematic review of outcomes measured in trials

The site uses cookies, some may have been set already. Please refer to our privacy policy & cookie usage statement.
If you continue to use the site we'll assume you're happy to accept the cookies.