Core Outcome Measures in Effectiveness Trials

COMMIT: Core Outcome Measures for Infertility Trials

General Information

Summary:
Infertility is a disease of the reproductive system defined by the failure to achieve a clinical pregnancy following twelve months or more of regular unprotected sexual intercourse. Randomised trials evaluating treatments for subfertility have reported many different outcomes and outcome measures. Such variation contributes to an inability to compare and combine individual trials, limiting the usefulness of evidence synthesis to inform clinical practice.

Contributors:
Dr James M N Duffy
Balliol College, University of Oxford
james.duffy@balliol.ox.ac.uk

Professor Cindy Farquhar
Cochrane Gynaecology and Fertility Group, University of Auckland

Further Study Information

Current Stage:
Ongoing
Date:
August 2017 - December 2018
Funding source(s):
Royal Society of New Zealand Catalyst Fund

Health Area

Disease Category
Gynaecology

Disease Name
Infertility

Target Population

Age Range
16 - 45

Sex
Female


Nature / type of Intervention
Any

Method(s)

Consensus meeting
Delphi process

An international steering group including healthcare professionals, researchers, and people with lived experience of subfertility, has been formed to guide the development of this core outcome set. Potential outcomes will be identified through a comprehensive literature review and will be entered into an online Delphi survey. Key stakeholders, including healthcare professionals, researchers, and people with lived experience of subfertility will be invited to participate. Participants will be invited to score individual outcomes on a nine-point Likert scale anchored between 1 (not important) and 9 (critical). Repeated reflection and rescoring should promote convergence towards consensus ‘core’ outcomes. High-quality outcome measures will be associated with core outcomes.


Stakeholders Involved

Charities
Clinical experts
Conference participants
Consumers (patients)
Epidemiologists
Families
Governmental agencies
Journal editors
Methodologists
Patient/ support group representatives
Pharmaceutical industry representatives
Policy makers
Regulatory agency representatives
Researchers
Service commissioners
Service providers
Service users
Statisticians

Study Type

COS for clinical trials or clinical research

The site uses cookies, some may have been set already. Please refer to our privacy policy & cookie usage statement.
If you continue to use the site we'll assume you're happy to accept the cookies.