Core Outcome Measures in Effectiveness Trials

COMMIT: Core Outcome Measures for Infertility Trials

General Information

Infertility is a disease of the reproductive system defined by the failure to achieve a clinical pregnancy following twelve months or more of regular unprotected sexual intercourse. Randomised trials evaluating treatments for subfertility have reported many different outcomes and outcome measures. Such variation contributes to an inability to compare and combine individual trials, limiting the usefulness of evidence synthesis to inform clinical practice.

Dr James M N Duffy
Balliol College, University of Oxford

Professor Cindy Farquhar
Cochrane Gynaecology and Fertility Group, University of Auckland

Further Study Information

Current Stage:
August 2017 - December 2018
Funding source(s):
Royal Society of New Zealand Catalyst Fund

Health Area

Disease Category

Disease Name

Target Population

Age Range
16 - 45


Nature / type of Intervention


Consensus meeting
Delphi process

An international steering group including healthcare professionals, researchers, and people with lived experience of subfertility, has been formed to guide the development of this core outcome set. Potential outcomes will be identified through a comprehensive literature review and will be entered into an online Delphi survey. Key stakeholders, including healthcare professionals, researchers, and people with lived experience of subfertility will be invited to participate. Participants will be invited to score individual outcomes on a nine-point Likert scale anchored between 1 (not important) and 9 (critical). Repeated reflection and rescoring should promote convergence towards consensus ‘core’ outcomes. High-quality outcome measures will be associated with core outcomes.

Stakeholders Involved

Clinical experts
Conference participants
Consumers (patients)
Governmental agencies
Journal editors
Patient/ support group representatives
Pharmaceutical industry representatives
Policy makers
Regulatory agency representatives
Service commissioners
Service providers
Service users

Study Type

COS for clinical trials or clinical research

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