Core Outcome Measures in Effectiveness Trials

A scoping review of outcomes related to orthodontic treatment measured in cleft lip and palate.

General Information

Abstract:
The aim of this study was to identify and summarize the outcomes measured in orthodontic studies of children with cleft lip and/or palate. The objectives were to categorize the outcomes into pre-determined domains and to explore whether any domains were under-represented. Electronic databases and grey literature were searched until December 2016 to identify all studies of orthodontic treatment interventions in children and adolescents with cleft lip and palate. Abstracts and subsequently eligible full-text articles were screened independently and in duplicate by two reviewers. All reported outcome measures were identified and categorized into six predetermined outcome domains. The search identified 833 abstracts. The majority of studies did not assess orthodontic interventions and were therefore not eligible for inclusion. Consequently, following screening 71 eligible articles were retrieved in full, of which 40 met the inclusion criteria. Morphological features of malocclusion were measured in 27 studies (68%) and adverse effects of orthodontic treatment in 10 (25%). Functional status (n=4; 10%), physical consequences of malocclusion (n=3; 7.5%), quality of life (n=3; 7.5%) and health resource utilization (n=2; 5%) were rarely considered. Relatively few studies concerning patients with cleft lip and palate focused on orthodontic interventions. Most of the identified outcomes were concerned with measuring morphological treatment-related changes and do not reflect patient perspectives.

Aim:
The aim of this study was to identify and summarize the outcomes measured in orthodontic studies of children with cleft lip and/or palate.

Authors:
Tsichlaki, O'Brien, Johal, Fleming

Publication

Journal:
Orthodontics and Craniofacial Research
Volume:
20
Issue:
2
Pages:
55 - 64
Year:
2017
DOI:
Further Study Information

Date:
Funding source(s):
Funding from the British Orthodontic Society and Royal College of Surgeons, England, to support this research is gratefully acknowledged.

Health Area

Disease Category
Dentistry & oral health

Disease Name
Cleft palate

Target Population

Age Range
-

Sex
Unknown


Nature / type of Intervention
Unknown

Method(s)

Systematic review

Stakeholders Involved

Unknown

Study Type

Systematic review of outcomes measured in trials

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