Core Outcome Measures in Effectiveness Trials

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

General Information

The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults, published in 2010, has found broad acceptance by physicians and investigators caring for patients with AML. Recent advances, for example, in the discovery of the genomic landscape of the disease, in the development of assays for genetic testing and for detecting minimal residual disease (MRD), as well as in the development of novel antileukemic agents, prompted an international panel to provide updated evidence- and expert opinion-based recommendations. The recommendations include a revised version of the ELN genetic categories, a proposal for a response category based on MRD status, and criteria for progressive disease.

Dohner, H. Estey, E. Grimwade, D. Amadori, S. Appelbaum, F. R. Buchner, T. Dombret, H. Ebert, B. L. Fenaux, P. Larson, R. A. Levine, R. L. Lo-Coco, F. Naoe, T. Niederwieser, D. Ossenkoppele, G. J. Sanz, M. Sierra, J. Tallman, M. S. Tien, H. F. Wei, A. H. Lowenberg, B. Bloomfield, C. D.


424 - 447
Further Study Information

Not stated
Funding source(s):
H.D¨ohner was supported by SFB 1074 “Experimental models and clinical translation in leukemia” funded by the Deutsche Forschungsgemeinschaft (DFG). D.G. was grateful for support from the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (grant reference RP-PG-0108-10093). J.S. was supported by grants from the Ag`encia de Gesti´o d’Ajuts Universitaris i de Recerca (AGAUR) 2014SGR-1281, Instituto de Salud Carlos III (ISCIII) RD12/0036/0071 and Fondo de Investigaci´on en Salud (FIS) PI14/00450. F.L.-C. was supported by Associazione Italiana per la Ricerca sul Cancro grant AIRC I.G. 5916. C.D.B. was supported by National Institutes of Health National Cancer Institute grants CA180861, CA016058.

Health Area

Disease Category

Disease Name
Leukemia (acute myeloid)

Target Population

Age Range
18 - 100


Nature / type of Intervention


Literature review
Semi structured discussion

The panel included 22 international members with recognized clinical and research expertise in AML. The panel met 3 times. Literature searches, categorization of evidence, and arrival at consensus were done.

Stakeholders Involved

Clinical experts

Study Type

COS for clinical trials or clinical research

The site uses cookies, some may have been set already. Please refer to our privacy policy & cookie usage statement.
If you continue to use the site we'll assume you're happy to accept the cookies.