Core Outcome Measures in Effectiveness Trials

Outcome Measures in Polymyalgia Rheumatica. A Systematic Review

General Information

Abstract:
OBJECTIVE: To identify the instruments used to assess polymyalgia rheumatica (PMR) in published studies. METHODS: A systematic literature review of clinical trials and longitudinal observational studies related to PMR, published from 1970 to 2014, was carried out. All outcome and assessment instruments were extracted and categorized according to core areas and domains, as defined by the OMERACT (Outcome Measures in Rheumatology) Filter 2.0. RESULTS: Thirty-five articles (3221 patients) were included: 12 randomized controlled trials (RCT); 3 nonrandomized trials; and 20 observational studies. More than 20 domains were identified, measured by 29 different instruments. The most frequently used measures were pain, morning stiffness, patient global assessment and physician global assessment, erythrocyte sedimentation rate, and C-reactive protein. The definition of outcomes varied considerably between studies. CONCLUSION: The outcome measures and instruments used in PMR are numerous and diversely defined. The establishment of a core set of validated and standardized outcome measurements is needed.

Authors:
Duarte, C. Ferreira, R. J. Mackie, S. L. Kirwan, J. R. Pereira da Silva, J. A. Omeract Polymyalgia Rheumatica Special Interest Group

Publication

Journal:
J Rheumatol
Volume:
42
Issue:
12
Pages:
2503 - 11
Year:
2015
DOI:
Further Study Information

Date:
Funding source(s):

Health Area

Disease Category
Rheumatology

Disease Name
Polymyalgia rheumatica

Target Population

Age Range
-

Sex
Unknown


Nature / type of Intervention
Unknown

Method(s)

Unknown

Stakeholders Involved

Unknown

Study Type

Systematic review of outcomes measured in trials

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