Core Outcome Measures in Effectiveness Trials

A systematic review of postoperative pain outcome measurements utilised in regional anesthesia randomized controlled trials

General Information

Abstract:
Introduction: Regional anesthesia is a rapidly growing subspecialty. There are few published meta-analyses exploring pain outcome measures utilized in regional anesthesia randomized controlled trials, which may be due to heterogeneity in outcomes assessed. This systematic review explores postoperative pain outcomes utilized in regional anesthesia randomized controlled trials (RCTs).

Methods: A literature search was performed using three databases (Medline, Embase and CINAHL). Regional anesthesia RCTs with postoperative pain as a primary outcome were included if written in English and published in one of the top-20 impact factor journals in the last 12 years. Study quality was assessed using the Cochrane Collaboration’s tool for assessing risk of bias.

Results: From the 31 included articles, 15 different outcome measures in total were used to assess postoperative pain. The most commonly (16/31) used outcome measures were verbal numerical grading of pain out of 10, total opioid consumption, and visual analogue scale 10 cm (VAS). The need for analgesia was used as an outcome measure where studies did not use a pain rating score. Ten studies reported pain scores on activity and 27/31 studies utilised =2 pain outcomes. Time of measurement of pain score also varied with a total of 51 different time points used in total.

Conclusion: Analysis of the articles demonstrated heterogeneity and inconsistency in choice of pain outcome and time of measurement within regional anesthesia studies. Identification of these pain outcomes utilized can help to create a definitive list of core outcomes, which may guide future researchers when designing such studies.

Authors:
E Pushpanathan¹, T Setty², B Carvalho3, P Sultan4

Publication

Journal:
Volume:
Issue:
Pages:
-
Year:
2018
DOI:
Further Study Information

Date:
Funding source(s):

Health Area

Disease Category
Anaesthesia & pain control

Disease Name
N/A

Target Population

Age Range
-

Sex
Unknown


Nature / type of Intervention
Procedure

Method(s)

Unknown

Stakeholders Involved

Unknown

Study Type

Systematic review of outcome measures/measurement instruments

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