Core Outcome Measures in Effectiveness Trials

Neuropsychological outcomes following paediatric temporal lobe surgery for epilepsies: Evidence from a systematic review

General Information

Abstract:
OBJECTIVE: The systematic review aimed to assess the neuropsychological outcomes of temporal lobe resections for epilepsy in children. Additional objectives included determining whether earlier age at surgery leads to better neuropsychological outcomes; the relationships between and predictors of these outcomes. METHODS: Using advanced search terms, a systematic review of electronic databases was conducted, comprising MEDLINE, Embase, PsycINFO, Global Health, Web of Science and CINAHL. Included studies reported on outcome following neurosurgical treatment for epilepsy. Specifically, studies were included if they reported neuropsychological outcomes and were concerned only with temporal lobe resection. RESULTS: 73 studies met inclusion criteria. For reported neuropsychological outcomes, the majority of participants remained stable after surgery; some declined and some improved. There was some evidence for increased material-specific memory deficits after temporal lobe surgery based on resection side, and more positive cognitive outcome for those with lower pre-surgical ability level. SIGNIFICANCE: Retrieved evidence highlights the need for improvements to quality of methodology and reporting. Appropriately designed prospective multicentre trials should be conducted with adequate follow-up for long-term outcomes to be measured. Core outcome measures should be agreed between centres. This would permit higher quality evidence so that clinicians, young people and their families may make better informed decisions about whether or not to proceed with surgery and likely post-operative profile.

Authors:
Flint, A. E. Waterman, M. Bowmer, G. Vadlamani, G. Chumas, P. Morrall, Mchj

Publication

Journal:
Seizure
Volume:
52
Issue:
Pages:
89 - 116
Year:
2017
DOI:
Further Study Information

Date:
Funding source(s):

Health Area

Disease Category
Neurology

Disease Name
Epilepsy

Target Population

Age Range
0 - 19

Sex
Either


Nature / type of Intervention
Surgery

Method(s)

Systematic review

Stakeholders Involved

Study investigators

Study Type

COS for clinical trials or clinical research

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