Core Outcome Measures in Effectiveness Trials

A systematic review assessing non-pharmacological conservative treatment studies for people with non-inflammatory multi-joint pain: clinical outcomes and research design considerations

General Information

Abstract:
To systematically review the evidence to determine the clinical outcomes and the important methodological quality features of interventional studies on adults with non-inflammatory multi-joint pain (MJP). Systematic search of published and unpublished literature using the databases: AMED, CINAHL, MEDLINE, EMBASE, psycINFO, SPORTDiscus, PEDro, OpenGrey, the EU Clinical Trials Register, World Health Organization International Clinical Trial Registry Platform, ClinicalTrials.gov and the ISRCTN registry (search: inception to 19th October 2017). All papers reporting the clinical outcomes of non-pharmacological interventions for people with non-inflammatory MJP were included. Studies were critically appraised using the Downs and Black Critical Appraisal and the TIDieR reporting checklists. Data were analysed using a Best Evidence Synthesis approach. From 3824 citations, four papers satisfied the eligibility criteria. Three studies reported outcomes from multidisciplinary rehabilitation programmes and one study reported the findings of a spa therapy intervention. All interventions significantly improved pain, function and quality of life in the short-term. There was limited reporting of measures for absenteeism, presenteeism and psychosocial outcomes. The evidence was 'weak', and due to a lack of controlled trials, there is limited evidence to ascertain treatment effectiveness. Design consideration for future trials surround improved reporting of participant characteristics, interventions and the standardisation of core outcome measures. There is insufficient high-quality trial data to determine the effectiveness of treatments for non-inflammatory MJP. Given the significant health burden which this condition presents on both individuals and wider society, developing and testing interventions and accurately reporting these, should be a research priority. Registration PROSPERO (CRD42013005888).

Authors:
Comer, C. Smith, T. O. Drew, B. Raja, R. Kingsbury, S. R. Conaghan, P. G.

Publication

Journal:
Rheumatol Int
Volume:
38
Issue:
3
Pages:
331 - 341
Year:
2018
DOI:
Further Study Information

Date:
- October 2017
Funding source(s):
SRK and PGC are funded in part by the Arthritis Research UK Experimental Osteoarthritis Treatment Centre (Grant number 20083) and the National Institute for Health Research (NIHR) Leeds Biomedical Research Centre. BD is funded by a NIHR Clinical Doctoral Research Fellowship (CDRF-2013-04-044). This article presents independent research funded by the NIHR

Health Area

Disease Category
Anaesthesia & pain control
Orthopaedics & trauma
Rheumatology

Disease Name
Non-inflammatory multi-joint pain (MJP)

Target Population

Age Range
16 - 100

Sex
Either


Nature / type of Intervention
Behavioural
Device
Exercise
Nonpharmacological
Physical
Psychological & behavioural

Method(s)

Systematic review

Stakeholders Involved

None

Study Type

Recommendations made
Systematic review of outcomes measured in trials

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