Core Outcome Measures in Effectiveness Trials

Core Outcomes in Aphasia Treatment Research: An e-Delphi Consensus Study of International Aphasia Researchers.

General Information

Abstract:
Purpose:
The purpose of this article is to identify outcome constructs that aphasia researchers consider essential to measure in all aphasia treatment research.

Method:
Purposively sampled researchers were invited to participate in a 3-round e-Delphi exercise. In Round 1, an open-ended question was used to elicit important outcome constructs; responses were analyzed using inductive content analysis. In Rounds 2 and 3, participants rated the importance of each outcome using a 9-point rating scale. Outcomes reaching predefined consensus criteria were further analyzed using International Classification of Functioning, Disability and Health coding.

Results:
Eighty researchers commenced Round 1, with 72 completing the entire survey. High response rates (= 85%) were achieved in subsequent rounds. Consensus was reached on 6 outcomes: (a) language functioning in modalities relevant to study aims, (b) impact of treatment from the perspective of the person with aphasia (PWA), (c) communication-related quality of life, (d) satisfaction with intervention from the perspective of the PWA, (e) satisfaction with ability to communicate from the perspective of the PWA, and (f) satisfaction with participation in activities from the perspective of the PWA.

Conclusions:
Consensus was reached that it is essential to measure language function and specific patient-reported outcomes in all aphasia treatment research. These results will contribute to the development of a core outcome set.

Aim:
To identify outcome constructs which aphasia researchers consider essential to measure in all aphasia treatment research.

Authors:
Sarah J. Wallace, Linda Worrall, & Tanya Rose
The University of Queensland
Guylaine Le Dorze
University of Montreal

Publication

Journal:
American Journal of Speech-Language Pathology
Volume:
25
Issue:
Pages:
S729 - S742
Year:
2016
DOI:
Further Study Information

Date:
March 2014 - February 2015
Funding source(s):
Australia Post-Graduate Award

Health Area

Disease Category
Neurology

Disease Name
Aphasia

Target Population

Age Range
18 - 100

Sex
Either


Nature / type of Intervention
Any

Method(s)

Delphi process

Purposively sampled researchers were invited to participate in a three-round e-Delphi exercise. In round 1, an open-ended question was used to elicit important outcome constructs; responses were analysed using inductive content analysis. In rounds 2 and 3, participants rated the importance of each outcome using a 9-point rating scale. Outcomes reaching pre-defined consensus criteria were further analysed using ICF coding.

Protocol: http://ajslp.pubs.asha.org/article.aspx?articleid=2594841


Stakeholders Involved

Researchers

Study Type

COS for clinical trials or clinical research

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