Core Outcome Measures in Effectiveness Trials

Identification of outcome domains measured in the management of paediatric lateral humeral condyle fractures. A Systematic review.

General Information

Summary:
Background

Lateral humeral condyle fractures are the second most common traumatic injury to the skeletally immature elbow. Management strategies have been based on the presumption that displacement of the fracture will result in complications such as nonunion, delayed union, arthritis and loss of function. The majority of displaced fractures are treated with Kirschner wire fixation after closed or open reduction. There is however a significant lack of consensus in the literature. When trying to establish the most effective treatment, we must first look at what the core outcome areas are, as described by OMERACT: life impact, resource use, death, pathophysiology manifestations and adverse events. These are then subdivided into specific outcome domains related to the areas. Establishing a core outcome set allows standardisation of outcome measurement for us in both research, and also to compare outcomes in clinical practice. Its inclusion in future research enables meta-analysis to be performed which improves the value. The initial step is to identify a draft core outcome set from the literature, which will form the basis of further qualitative research in the form of a DELPHI study. Thus developing a stakeholder consensus on the core outcome set.

Objectives

The primary aim of this systematic review is to determine the outcome domains measured from eligible studies. Identification of any pre-existing validated core outcome set measurement tools will be a secondary objective.

Contributors:
Mr Robert Allen Stevenson, MB ChB FRCSEd (Tr&Orth) - Orthopaedic registrar, PhD project 1st Chapter. Affiliation with Alder Hey Children's hospital and University of Liverpool

Mr Daniel Perry MB ChB (Hons) PhD FRCS (Tr&Orth) - NIHR Scientist and Orthopaedic Consultant Surgeon. Affiliation with Alder Hey Children's Hospital and University of Liverpool

Dr Jamie Kirkham BSc MSc PhD, Lecturer in Medical Statistics. Affiliation with the University of Liverpool

Ms Sara Dorman MB ChB BMSc(Hons) MRCSEd, Orthopaedic Registrar. Affiliation with Health Education North West and the University of Liverpool.

Further Study Information

Current Stage:
Ongoing
Date:
January 2017 - March 2017
Funding source(s):

Health Area

Disease Category
Orthopaedics & trauma

Disease Name
Lateral Humeral Condyle Fractures

Target Population

Age Range
0 - 15

Sex
Either


Nature / type of Intervention
Any

Method(s)

Systematic review

The search was performed from September 2000 to September 2016 using MEDLINE, SCOPUS, CINAHL, AMED, EMBASE and CENTRAL. All study designs and languages where included in the search. Eligible studies where determined by 2 independent reviewers using predetermined inclusion and exclusion criteria. Data extraction of these articles was then performed using the COVIDENCE software and the data collection form. Critical appraisal of the articles was not undertaken. Domains identified were allocated to predetermined core outcome areas.


Stakeholders Involved

Clinical experts
Consumers (caregivers)
Consumers (patients)
Families

Study Type

Systematic review of outcome measures/measurement instruments

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