Core Outcome Measures in Effectiveness Trials

The COMPARE (Core Outcome Measures PAediatRic Endocrinology) Initiative

General Information

Summary:
The COMPARE (Core Outcome Measures PAediatRic Endocrinology) Initiative is an international not-for-profit research collaboration working towards an international consensus on definitions and standardised outcome measures for therapeutic trials (and epidemiological studies) in Paediatric Endocrinology.

The outcomes are developed based on shared priorities between patients, families and caregivers, clinicians, researchers, policy makers and other relevant stakeholders.

Contributors:
Principal investigator: Dr Richard G McGee

Further Study Information

Current Stage:
Planning
Date:
Funding source(s):
N/A

Health Area

Disease Category
Endocrine & metabolic

Disease Name
Paediatric Endocrinology

Target Population

Age Range
0 - 18

Sex
Either


Nature / type of Intervention
Any

Method(s)

Consensus meeting
Delphi process
Literature review
Systematic review

The process is based on the methods used in many other research areas, in particular the Outcome Measures in Rheumatology (OMERACT) initiative and the World Health Organisation (WHO)-endorsed OMERACT framework. This process is underpinned by the values of: partnership, transparency, equity, trust, respect, evidence, and diversity.
Each ‘domain’ will run individually under the guidance of the COMPARE steering group. For example, the COMPARE-Diabetes group will develop core outcomes for trials related to paediatric diabetes.
There is a five phase process to the creation of a core outcome set: study protocol, systematic review of published outcomes, online Delphi survey, consensus workshop, and publication of core outcome set.


Stakeholders Involved

Clinical experts
Conference participants
Consumers (caregivers)
Consumers (patients)
Device manufacturers
Economists
Epidemiologists
Families
Governmental agencies
Methodologists
Patient/ support group representatives
Pharmaceutical industry representatives
Policy makers
Regulatory agency representatives
Researchers
Service commissioners
Service providers
Service users

Study Type

COS for clinical trials or clinical research
COS for practice

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