Core Outcome Measures in Effectiveness Trials

Defining a standard set of patient-centred outcomes for lung cancer

General Information

Abstract:
In lung cancer, outcome measurement has been mostly limited to survival. Proper assessment of the value of lung cancer treatments, and the performance of institutions delivering care, requires more comprehensive measurement of standardised outcomes.

The International Consortium for Health Outcomes Measurement convened an international, multidisciplinary working group of patient representatives, medical oncologists, surgeons, radiation oncologists, pulmonologists, palliative care specialists, registry experts and specialist nurses to review existing data and practices. Using a modified Delphi method, the group developed a consensus recommendation (“the set”) on the outcomes most essential to track for patients with lung cancer, along with baseline demographic, clinical and tumour characteristics (case-mix variables) for risk adjustment.

The set applies to patients diagnosed with nonsmall cell lung cancer and small cell lung cancer. Our working group recommends the collection of the following outcomes: survival, complications during or within 6 months of treatment and patient-reported domains of health-related quality of life including pain, fatigue, cough and dyspnoea. Case-mix variables were defined to improve interpretation of comparisons.

We defined an international consensus recommendation of the most important outcomes for lung cancer patients, along with relevant case-mix variables, and are working to support adoption and reporting of these measures globally.

Aim:
To define a recommended standard set of outcomes and corresponding baseline demographic, clinical and tumourcharacteristics (case-mix variables) for patients with lung cancer.

Authors:
Kimberley S. Mak
Annelotte C.M. van Bommel
Caleb Stowell
Janet L. Abrahm
Matthew Baker
Clarissa S. Baldotto
David R. Baldwin
Diana Borthwick
David P. Carbone
Aileen B. Chen
JesmeFox
Tom Haswell
Marianna Koczywas
Benjamin D. Kozower
Reza J. Mehran
Franz M. Schramel
Suresh Senan
Robert G. Stirling
Jan P. van Meerbeeck
Michel W.J.M. Wouters
Michael D. Peake
on behalf of the Lung Cancer Working Group of ICHOM

Publication

Journal:
European Respiratory Journal
Volume:
49
Issue:
5
Pages:
-
Year:
2016
DOI:
Further Study Information

Date:
Funding source(s):
Alliance of Dedicated Cancer Centers

Health Area

Disease Category
Cancer

Disease Name
Lung cancer

Target Population

Age Range
-

Sex
Unknown


Nature / type of Intervention
Unknown

Method(s)

Unknown

Stakeholders Involved

Unknown

Study Type

COS for practice

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