Developing a Core outcome set of Traditional Chinese Medicine on Stable stage of COPD

Chronic obstructive pulmonary disease (COPD) is a common respiratory chronic disease, which has a long course, recurrent attacks and protracted refractory. It belongs to the category of "cough", "asthma syndrome" and "lung distention" in traditional Chinese medicine. Chronic obstructive pulmonary disease is a chronic bronchitis and / or emphysema with the characteristics of airflow obstruction, which can further develop into pulmonary heart disease and respiratory failure. It is related to the abnormal inflammatory reaction of harmful gases and harmful particles, with high morbidity and mortality. COPD is a more complex disease, according to the course of disease can be divided into acute exacerbation and stable period, patients in acute exacerbation will experience cough, expectoration, asthma, fever and other symptoms, Severe COPD may cause anorexia, depression, hemoptysis and other symptoms. The main purpose of stable treatment is to reduce its acute attack, delay the development of its disease and reduce its mortality. There is a clinical need to actively explore effective treatment programs, although it has a certain effect, studies have pointed out that traditional medicine treatment course is longer and there are more adverse reactions. The use of traditional Chinese medicine in the treatment of chronic obstructive pulmonary disease, not only can effectively avoid the disadvantages of traditional drug treatment, but also achieves the goal of treating both symptoms and root causes, so as to comprehensively improve the prognosis and quality of life. TCM related clinical trials have been on the rise annually. However, the heterogeneity of these trial results pose as an obstacle for synthesizing clinical results in meta-analyses, thus reducing the value of clinical trials. There is also a risk of bias for selective reporting in clinical trials. Therefore, it is necessary and urgent to establish a core outcome set (COS) on TCM for Chronic obstructive pulmonary disease.


Principal investigator:
Ming Ren, Baokang Hospital Affiliated to Tianjin University of traditional Chinese Medicine, Tianjin, China
Junhua Zhang, Mingyan Zhang, Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, China

Other contributors: Huiyi Zhao, Xiangyu Zhang, Tianjin University of Traditional Chinese Medicine, Tianjin, China

Further Study Information

Current Stage: Ongoing
Date: January 2020 - June 2022
Funding source(s): None

Health Area

Disease Category: Lungs & airways

Disease Name: Chronic obstructive pulmonary disease (COPD)

Target Population

Age Range: 0 - 100

Sex: Either

Nature of Intervention: Complementary and alternative medicine (CAM) therapy, Traditional Chinese Medicine

Stakeholders Involved

- Clinical experts
- Conference participants
- Consumers (patients)
- Researchers

Study Type

- COS for practice


- Consensus conference
- Delphi process
- Interview
- Systematic review

(1) Systematic literature review
(2) Qualitative semi-structured interviews
(3) Two rounds Delphi Survey
(4) Consensus conference

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