COMET Initiative | Development of a Core Outcome Set for Neonatal Sepsis

Development of a Core Outcome Set for Neonatal Sepsis

Neonatal sepsis is a major public health problem that may cause an increased risk of death, neurodevelopmental delay/impairment, physical growth impairment, and bronchopulmonary dysplasia among newborns. There is heterogeneity in the outcomes measured and reported in trials evaluating treatments of neonatal sepsis. In this project, we will develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for neonatal sepsis. The study will be conducted in four stages: (1) systematic review, (2) Delphi survey (3) consensus meetings and (4) dissemination and implementation strategy.

Contributors

Declan Devane (Supervisor)
Evidence Synthesis Ireland, National University of Ireland, Galway, Galway, Ireland.
School of Nursing and Midwifery, National University of Ireland, Galway, Galway, Ireland.

Petek Eylul Taneri (Principal Investigator)
School of Nursing and Midwifery, National University of Ireland, Galway, Galway, Ireland.

Further Study Information

Current Stage: Completed – pending publication
Date: June 2022 - October 2023
Funding source(s): Health Research Board (Ireland)

Health Area

Disease Category: Neonatal care

Disease Name: Sepsis

Target Population

Age Range: 0 - 1

Sex: Either

Nature of Intervention: Any

Stakeholders Involved

- Clinical experts
- Families
- Patient/ support group representatives
- Researchers

Study Type

- COS for clinical trials or clinical research
- COS for practice

Method(s)

- Consensus meeting
- Delphi process
- Literature review
- Systematic review

The study will be conducted in four stages: (1) systematic review, (2) Delphi survey (3) consensus meetings and (4) dissemination and implementation strategy.