Objective: There is a lack of consensus regarding clinician- and patient-reported
outcomes for oral lichen planus (OLP). The World Workshop on Oral Medicine
Outcomes Initiative for the Direction of Research (WONDER Project) aims to develop
a core outcome set (COS) for OLP, which would inform the design of clinical trials, and
importantly, facilitate meta-analysis, leading to the establishment of more robust
evidence for the management of this condition and hence improved patient care.
Study Design: Ovid MEDLINE, Embase, CINAHL, CENTRAL, and Clinicaltrials.gov
were searched for interventional studies (randomized controlled trials, controlled
clinical trials, and case series including =5 participants) on OLP and oral lichenoid
reactions published between January 2001 and March 2022 without language
restriction. All reported primary and secondary outcomes were extracted.
Results: The searches yielded 9,135 records, and 291 studies were included after
applying the inclusion criteria. A total of 422 outcomes were identified. These were
then grouped based on semantic similarity condensing the list to 69 outcomes. The most
frequently measured outcomes were pain (51.9%), clinical grading of the lesions
(29.6%), lesion size/extension/area (27.5%), and adverse events (17.5%).
Conclusion: As a first step in developing a COS for OLP, we summarized the outcomes
that have been used in interventional studies over the past two decades, which are
numerous and heterogeneous.
To identify all primary and secondary outcomes reported in interventional studies on OLP over
the past two decades
Rosa María López-Pintor, Márcio Diniz-Freitas, Shilpa Shree Kuduva Ramesh, J Amadeo Valdéz, HongxiaDan, Caroline Bissonnette, Catherine Hong, Arwa Farag, Martin S Greenberg, Michael T Brennan, Nancy W Burkhart, Jane F Setterfield, Sook-Bin Woo, Thomas P Sollecito, Richeal Ni Riordain, Jennifer Taylor, Jairo Robledo-Sierra
Disease Category: Dentistry & oral health
Disease Name: Oral lichen planus
Age Range: Unknown
Sex: Either
Nature of Intervention: Drug
- Systematic review of outcomes measured in trials
- Systematic review
Objective: There is a lack of consensus regarding clinician- and patient-reported
outcomes for oral lichen planus (OLP). The World Workshop on Oral Medicine
Outcomes Initiative for the Direction of Research (WONDER Project) aims to develop
a core outcome set (COS) for OLP, which would inform the design of clinical trials, and
importantly, facilitate meta-analysis, leading to the establishment of more robust
evidence for the management of this condition and hence improved patient care.
Study Design: Ovid MEDLINE, Embase, CINAHL, CENTRAL, and Clinicaltrials.gov
were searched for interventional studies (randomized controlled trials, controlled
clinical trials, and case series including =5 participants) on OLP and oral lichenoid
reactions published between January 2001 and March 2022 without language
restriction. All reported primary and secondary outcomes were extracted.
Results: The searches yielded 9,135 records, and 291 studies were included after
applying the inclusion criteria. A total of 422 outcomes were identified. These were
then grouped based on semantic similarity condensing the list to 69 outcomes. The most
frequently measured outcomes were pain (51.9%), clinical grading of the lesions
(29.6%), lesion size/extension/area (27.5%), and adverse events (17.5%).
Conclusion: As a first step in developing a COS for OLP, we summarized the outcomes
that have been used in interventional studies over the past two decades, which are
numerous and heterogeneous