Developing a Core Outcome Set for Necrotising Soft Tissue Infections: a modified Delphi study

A search of the COMET database was undertaken - currently no COS exists for NSTI. An inventory of outcomes identified in a (pre-print) systematic review of all NSTI literature published in the last 10 years involving > 5 cases in the English language has been created. The outcomes were grouped and sorted into Domains, and will be used to provide outcomes to an expert panel to determine a COS using a modified Delphi approach.

Aim

To develop a COS for NSTI

Contributors

Bridget Devaney - PI
Joe Wackett
Aidan Burrell
Vikash Yogaraj
Morten Hedetoft
Ole Hyldegaard
Biswadev Mitra - supervisor

Further Study Information

Current Stage: Ongoing
Date: June 2023 - June 2024
Funding source(s): None


Health Area

Disease Category: Infectious disease

Disease Name: Necrotizing soft-tissue infections

Target Population

Age Range: 0

Sex: Either

Nature of Intervention: Any

Stakeholders Involved

- Clinical experts
- Conference participants
- Consumers (caregivers)
- Consumers (patients)
- Researchers

Study Type

- COS for clinical trials or clinical research
- COS for practice

Method(s)

- Consensus meeting
- Delphi process
- Focus group(s)
- Literature review
- Semi structured discussion
- Systematic review

Outcomes identified in the systematic review will be provided to an expert panel for 2 - 3 rounds of voting as required to determine a core outcome set, using DelphiManager software. Consensus for designation as a “Core Outcome” is defined a priori as: greater than or equal to 70% of responses rating the domain as “Critical” (i.e., a score = 7) and less than or equal to 15% of responses rating the domain as “Not Important” (i.e., score = 3) . Focus groups, semi-structured discussion meetings/workshops will be utilised as required.