COMET Initiative | World Workshop on Oral Medicine VIII: Development of a core outcome set for oral lichen planus: a systematic review of outcome domains

World Workshop on Oral Medicine VIII: Development of a core outcome set for oral lichen planus: a systematic review of outcome domains

Objective. There is a lack of consensus regarding clinician- and patient-reported oral lichen planus (OLP) outcomes. The World
Workshop on Oral Medicine Outcomes Initiative for the Direction of Research (WONDER) Project aims to develop a core outcome set (COS) for OLP, which would inform the design of clinical trials and, importantly, facilitate meta-analysis, leading to the
establishment of more robust evidence for the management of this condition and hence improved patient care.
Study Design. Ovid MEDLINE, Embase, CINAHL, CENTRAL, and Clinicaltrials.gov were searched for interventional studies (randomized controlled trials, controlled clinical trials, and case series including 5 participants) on OLP and oral lichenoid reactions
published between January 2001 and March 2022 without language restriction. All reported primary and secondary outcomes
were extracted.
Results. The searches yielded 9,135 records, and 291 studies were included after applying the inclusion criteria. A total of 422
outcomes were identified. These were then grouped based on semantic similarity, condensing the list to 69 outcomes. The most
frequently measured outcomes were pain (51.9%), clinical grading of the lesions (29.6%), lesion size/extension/area (27.5%),
and adverse events (17.5%).
Conclusion. As a first step in developing a COS for OLP, we summarized the outcomes that have been used in interventional studies over the past 2 decades, which are numerous and heterogeneous. (Oral Surg Oral Med Oral Pathol Oral Radiol
2023;135:772780)

Contributors

Rosa Maria Lopez-Pintor, Marcio Diniz-Freitas, Shilpa Shree Kuduva Ramesh, J. Amadeo Valdez, Hongxia Dan, Caroline Bissonnette, Catherine Hong, Arwa Farag, Martin S. Greenberg, Michael T. Brennan, Nancy W. Burkhart, Jane F. Setterfield, Sook-Bin Woo, Thomas P. Sollecito, Richeal Ni Riordain, Jennifer Taylor, Jairo Robledo-Sierra

Publication

Journal: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume: 135
Issue: 6
Pages: -
Year: 2023
DOI: 10.1016/j.oooo.2023.01.014

Further Study Information

Current Stage: Ongoing
Date: April 2020 - April 2024
Funding source(s): The WWOM VIII Steering Committee gratefully acknowledges the following organizations, companies, and individuals who provided financial support for WWOM VIII: American Academy of Oral Medicine, European Association of Oral Medicine, Church & Dwight Co Inc, Colgate Palmolive, and patients of Dr. Ross Kerr.

Health Area

Disease Category: Dentistry & oral health

Disease Name: Oral lichen planus

Target Population

Age Range: 18 - 100

Sex: Either

Nature of Intervention: Any

Stakeholders Involved

Study Type

- Systematic review of outcomes measured in trials

Method(s)

- Systematic review

Ovid MEDLINE, Embase, CINAHL, CENTRAL, and Clinicaltrials.gov were searched for interventional studies (randomized controlled trials, controlled clinical trials, and case series including 5 participants) on OLP and oral lichenoid reactions
published between January 2001 and March 2022 without language restriction. All reported primary and secondary outcomes
were extracted.