Outcomes of interventions in neonatal sepsis: A systematic review of qualitative research

Background
While a systematic review exists detailing neonatal sepsis outcomes from clinical trials, there remains an absence of a qualitative systematic review capturing the perspectives of key stakeholders.

Objectives
Our aim is to identify outcomes from qualitative research on any intervention to prevent or improve the outcomes of neonatal sepsis that are important to parents, other family members, healthcare providers, policymakers, and researchers as a part of the development of a core outcome set (COS) for neonatal sepsis.

Search Strategy
A literature search was carried out using MEDLINE, EMBASE, CINAHL, and PsycInfo databases.

Selection Criteria
Publications describing qualitative data relating to neonatal sepsis outcomes were included.

Data Collection and Analysis
Drawing on the concepts of thematic synthesis, texts related to outcomes were coded and grouped. These outcomes were then mapped to the domain headings of an existing model.

Main Results
Out of 6777 records screened, six studies were included. Overall, 19 outcomes were extracted from the included studies. The most frequently reported outcomes were those in the domains related to parents, healthcare workers and individual organ systemas such as gastrointestinal system. The remaining outcomes were classified under the headings of general outcomes, miscellaneous outcomes, survival, and infection.

Conclusions
The outcomes identified in this review are different from those reported in neonatal sepsis clinical trials, thus highlighting the importance of incorporating qualitative studies into COS development to encapsulate all relevant stakeholders' perspectives.

Aim

Our aim is to identify outcomes from qualitative research on any intervention to prevent or improve the outcomes of neonatal sepsis that are important to parents, other family members, healthcare providers, policymakers, and researchers as a part of the development of a core outcome set (COS) for neonatal sepsis.

Contributors

Petek Eylul Taneri, Declan Devane, Jamie Kirkham, Eleanor Molloy, Mandy Daly, Aoife Branagan, Denise Suguitani, James L. Wynn, Niranjan Kissoon, Kondwani Kawaza, Sinno H. P. Simons, LĂ­via Nagy Bonnard, Eric Giannoni, Tobias Strunk, Magdalena Ohaja, Kenneth Mugabe, Fiona Quirke, Kateregga Bazilio, Linda Biesty

Publication

Journal: International Journal of Gynecology & Obstetrics
Volume:
Issue:
Pages: -
Year: 2024
DOI: 10.1002/ijgo.15725

Further Study Information

Current Stage: Completed
Date:
Funding source(s): Health Research Board, Grant/AwardNumber: CTN-2021- 007


Health Area

Disease Category: Neonatal care

Disease Name: Sepsis

Target Population

Age Range: 0 - 1

Sex: Either

Nature of Intervention: Any

Stakeholders Involved

Study Type

- Systematic review of qualitative research

Method(s)

- Systematic review

A literature search was carried out using MEDLINE, EMBASE,CINAHL, and PsycInfo databases.