Introduction: Heterogeneity of outcomes reporting in clinical trials causes research waste. The use of core outcome set (COS) may address this issue. Previous research explored the use of COS in clinical trials, systematic reviews (SR), and clinical practice guidelines (CPGs). In addition, the value of COS in pre-clinical studies was also reported. However, none of the research explored the uptake of a COS in all stages of the evidence ecosystem, as well as pre-clinical studies. In this research, we will use the COS of acute myocardial infarction to explore the uptake of COS to examine its value in evidence production, synthesis, and translation.
Methods and analysis: Three Chinese databases (the China National Knowledge Infrastructure, SinoMed, and Wanfang Database) and three English databases (PubMed, the Cochrane Library, and Web of Science) will be searched. Registries of pre-clinical research, clinical trials, SR, and CPGs will also be searched. Outcomes from literature will be extracted verbatim and overlapped with COS. A framework will be used to examine the overlap of scope between COS and research. The Williamson/Clarke framework will be used to compare the correlation and difference of outcome domain between COS and research. Descriptive statistics will be used.
Shiguang Chai1, Hong Chen1, Shuling Liu1, Zhuo Chen1, Zhiyue Guan1, Ruijin Qiu1*, Hongcai Shang1,2*
1. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine , Beijing, China
2. Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Disease Category: Heart & circulation
Disease Name: Myocardial infarction
Age Range: Unknown
Sex: Either
Nature of Intervention: Any, Traditional Chinese Medicine
- None
- COS uptake study
- Systematic review
Three Chinese databases (the China National Knowledge Infrastructure, SinoMed, and Wanfang Database) and three English databases (PubMed, the Cochrane Library, and Web of Science) will be searched. Registries of pre-clinical research, clinical trials, SR, and CPGs will also be searched.