Numerous trials have evaluated the effectiveness of treatment interventions for Urinary Tract Infections (UTIs) in adult patients. However, inconsistency in the choice of outcomes reported have resulted in substantial challenges in synthesising evidence, ultimately limiting the capability to influence practice and policy.
The development of a core outcome set (COS), as a minimum set of agreed standardised outcomes to be reported in all trials, will address this problem. The development of a COS for interventions in the treatment of uncomplicated UTIs in adult patients would minimise the heterogeneity of outcome measures, allowing the efficient comparison and synthesis of trials in addition to encouraging a more complete reporting of outcomes which ultimately limits reporting bias.
To develop a core outcome set for interventions in the treatment of uncomplicated urinary tract infections (UTIs).Contributors
Prof Declan Devane
Dr Claire Beecher
Dr Sinead Duane
Prof Andrew Murphy
Dr Patricia Healy
Dr Akke Vellinga
Prof Micheal Moore
Prof Paul Little
Prof Martin Cormican
Dr Andrew Smyth
- COS for clinical trials or clinical research
- Consensus meeting
- Delphi process
- Systematic review
A three step approach will be used to concurrently develop the COS.
1. A systematic review to identify primary outcomes previously reported in clinical trials evaluating the interventions in the treatment of UTI’s;
2. Refinement of outcomes by an iterative process using a Delphi study.
3. A consensus development meeting with stakeholders will be held and the COS agreed upon prior to disseminating to stakeholders.