Cardiovascular disease is the leading cause of death in patients receiving hemodialysis. Currently, there is no standardized definition of myocardial infarction (MI) for patients receiving hemodialysis. Through an international consensus process MI was established as the core CVD measure for this population in clinical trials. The Standardised Outcomes in Nephrology Group—Hemodialysis (SONG-HD) initiative convened a multidisciplinary, international working group to address the definition of MI in this population. On the basis of
current evidence, the working group recommends using the Fourth Universal Definition of Myocardial Infarction with specific caveats with regard to the interpretation of “ischemic symptoms” and performing a baseline 12-lead electrocardiogram to facilitate interpretation of acute changes on subsequent tracings. The working group does not recommend obtaining baseline cardiac troponin values, though does recommend obtaining serial cardiac
biomarkers in settings where ischemia is suspected. The application of an evidence-based uniform definition should increase the reliability and accuracy of trial results.
Emma O’Lone, Fred S. Apple, James O. Burton, Fergus J. Caskey, Jonathan C. Craig,
Christopher R. deFilippi, Derek Forfang, Karen A. Hicks, Vivekanand Jha, Kenneth W. Mahaffey, Patrick B. Mark, Patrick Rossignol, Nicole Scholes-Robertson, Allison Jaure, Andrea K. Viecelli, Angela Y. Wang, David C. Wheeler, David White, Wolfgang C. Winkelmayer and Charles A. Herzog
Disease Category: Kidney disease
Disease Name: Chronic kidney disease
Age Range: 18 - 100
Sex: Either
Nature of Intervention: Procedure
- Clinical experts
- Recommendations for outcome measures (measurement/how)
- Semi structured discussion
The SONG-HD initiative convened an expert working group to discuss MI definitions most appropriate for use in clinical trials enrolling patients requiring hemodialysis