The COMPARE (Core Outcome Measures PAediatRic Endocrinology) Initiative is an international not-for-profit research collaboration working towards an international consensus on definitions and standardised outcome measures for therapeutic trials (and epidemiological studies) in Paediatric Endocrinology.
COMPARE-Diabetes will establish core outcome measures for trials of Type 1 Diabetes Mellitus in children.
The outcomes will be developed based on shared priorities between patients, families and caregivers, clinicians, researchers, policymakers and other relevant stakeholders.
Dr Richard G McGee
Prof Geoffrey Ambler
Dr Shubha Srinivasan
A/Prof Allison Tong
Ms Camilla Hanson
Disease Category: Endocrine & metabolic
Disease Name: Diabetes mellitus , Paediatric Endocrinology
Age Range: 0 - 18
Sex: Either
Nature of Intervention: Any
- Clinical experts
- Conference participants
- Consumers (caregivers)
- Consumers (patients)
- Device manufacturers
- Economists
- Epidemiologists
- Ethicists
- Families
- Governmental agencies
- Journal editors
- Methodologists
- Patient/ support group representatives
- Pharmaceutical industry representatives
- Policy makers
- Regulatory agency representatives
- Researchers
- Statisticians
- COS for clinical trials or clinical research
- COS for practice
- Consensus meeting
- Delphi process
- Focus group(s)
- Interview
- Literature review
- Survey
- Systematic review
The process is based on the methods used in many other research areas, in particular the Outcome Measures in Rheumatology (OMERACT) initiative and the World Health Organisation (WHO)-endorsed OMERACT framework. This process is underpinned by the values of: partnership, transparency, equity, trust, respect, evidence, and diversity.
Each ‘domain’ will run individually under the guidance of the COMPARE steering group. For example, the COMPARE-Diabetes group will develop core outcomes for trials related to paediatric diabetes.
There is a five phase process to the creation of a core outcome set: study protocol, systematic review of published outcomes, online Delphi survey, consensus workshop, and publication of core outcome set.